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MAPPING THE BINDING SITES OF THE OPIOID ANTIDOTE 

CLIENT

Professor Derek Ng

 

FORMAT

Print 11x17

Cinema 4D

Adobe Illustrator

DATE

July 2020

AUDIENCE

General, highly educated

PURPOSE

Despite being the only widely used opioid antidote, little is known about how Naloxone functions at the molecular level. In this mock magazine spread, recent research that maps the molecular binding sites of this opioid antidote on the mu opioid receptor and its impact on the development of novel antidote drugs is visualized. The educational goal of this assignment was to acquire, evaluate, and integrate molecular data from multiple sources (PDB, journal articles, UniProt, and PubChem) in order to craft a compelling visual narrative of a biomolecule.

PROCESS

Research
Research

press to zoom
Mind mapping
Mind mapping

press to zoom

press to zoom
Research
Research

press to zoom
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REFERENCES

Algera, M. H., Kamp, J., van der Schrier, R., van Velzen, M., Niesters, M., Aarts, L., Dahan, A., & Olofsen, E. (2019). Opioid-induced respiratory depression in humans: a review of pharmacokinetic–pharmacodynamic modelling of reversal. British Journal of Anaesthesia, 122(6), e168–e179. https://doi.org/10.1016/j.bja.2018.12.023

Dahan, A., Aarts, L., & Smith, T. (2010). Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression. Anesthesiology, 112(1), 226–238. https://doi.org/10.1097/aln.0b013e3181c38c25

Handal, K. A., Schauben, J. L., & Salamone, F. R. (1983). Naloxone. Annals of Emergency Medicine, 12(7), 438–445. https://doi.org/10.1016/s0196-0644(83)80343-6

Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O., & Kobilka, B. K. (2015). Structural insights into µ-opioid receptor activation. Nature, 524(7565), 315–321. https://doi.org/10.1038/nature14886

Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y., & Yeh, S. H. (2017). Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1865(3), 336–343. https://doi.org/10.1016/j.bbapap.2016.12.010

Magazine template found at <a href="https://www.freepik.com/psd/mockup">Mockup psd created by user17882893 - www.freepik.com</a>