MAPPING THE BINDING SITES OF THE OPIOID ANTIDOTE
CLIENT
Professor Derek Ng
FORMAT
Print 11x17
Cinema 4D
Adobe Illustrator
DATE
July 2020
AUDIENCE
General, highly educated
PURPOSE
Despite being the only widely used opioid antidote, little is known about how Naloxone functions at the molecular level. In this mock magazine spread, recent research that maps the molecular binding sites of this opioid antidote on the mu opioid receptor and its impact on the development of novel antidote drugs is visualized. The educational goal of this assignment was to acquire, evaluate, and integrate molecular data from multiple sources (PDB, journal articles, UniProt, and PubChem) in order to craft a compelling visual narrative of a biomolecule.
PROCESS
REFERENCES
Algera, M. H., Kamp, J., van der Schrier, R., van Velzen, M., Niesters, M., Aarts, L., Dahan, A., & Olofsen, E. (2019). Opioid-induced respiratory depression in humans: a review of pharmacokinetic–pharmacodynamic modelling of reversal. British Journal of Anaesthesia, 122(6), e168–e179. https://doi.org/10.1016/j.bja.2018.12.023
Dahan, A., Aarts, L., & Smith, T. (2010). Incidence, Reversal, and Prevention of Opioid-induced Respiratory Depression. Anesthesiology, 112(1), 226–238. https://doi.org/10.1097/aln.0b013e3181c38c25
Handal, K. A., Schauben, J. L., & Salamone, F. R. (1983). Naloxone. Annals of Emergency Medicine, 12(7), 438–445. https://doi.org/10.1016/s0196-0644(83)80343-6
Huang, W., Manglik, A., Venkatakrishnan, A. J., Laeremans, T., Feinberg, E. N., Sanborn, A. L., Kato, H. E., Livingston, K. E., Thorsen, T. S., Kling, R. C., Granier, S., Gmeiner, P., Husbands, S. M., Traynor, J. R., Weis, W. I., Steyaert, J., Dror, R. O., & Kobilka, B. K. (2015). Structural insights into µ-opioid receptor activation. Nature, 524(7565), 315–321. https://doi.org/10.1038/nature14886
Ke, Y. Y., Huang, Y. H., Chien, W. C., Loh, H. H., Chuang, J. Y., & Yeh, S. H. (2017). Mapping the naloxone binding sites on the mu-opioid receptor using cell-based photocrosslinkers. Biochimica et Biophysica Acta (BBA) - Proteins and Proteomics, 1865(3), 336–343. https://doi.org/10.1016/j.bbapap.2016.12.010
Magazine template found at <a href="https://www.freepik.com/psd/mockup">Mockup psd created by user17882893 - www.freepik.com</a>